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Description
Rig-I/DDX58 Recombinant Rabbit mAb (S-1419-114)Product Specification Host Rabbit Antigen Rig I DDX58 Synonyms Antiviral innate immune response receptor RIG I; ATP dependent RNA helicase DDX58; DEAD box protein 58; RIG I like receptor 1 (RLR 1); RNA sensor RIG I; Retinoic acid inducible gene 1 protein (RIG 1); Retinoic acid inducible gene I protein (RIG I); DDX58; RIGI Immunogen Synthetic Peptide Location Cytoplasm, Cell junction Accession O95786 Clone Number S 1419 114 Antibody Type Recombinant
Product Specification
| Host | Rabbit |
| Antigen | Rig-I/DDX58 |
| Synonyms | Antiviral innate immune response receptor RIG-I; ATP-dependent RNA helicase DDX58; DEAD box protein 58; RIG-I-like receptor 1 (RLR-1); RNA sensor RIG-I; Retinoic acid-inducible gene 1 protein (RIG-1); Retinoic acid-inducible gene I protein (RIG-I); DDX58; RIGI |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell junction |
| Accession | O95786 |
| Clone Number | S-1419-114 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
Rig-I (Retinoic acid-inducible gene I) is a crucial cytosolic pattern recognition receptor (PRR) in the innate immune system, belonging to the DExD/H-box RNA helicase family. It primarily detects viral RNA, such as short double-stranded RNA (dsRNA) with a 5'-triphosphate group (5'-ppp) or single-stranded RNA (ssRNA) with short stem-loop structures, thereby triggering antiviral immune responses. Structurally, Rig-I consists of two N-terminal tandem CARD domains (for signal transduction), a central DExD/H-box helicase domain (responsible for RNA binding and ATP hydrolysis), and a C-terminal regulatory domain (CTD, which specifically recognizes viral RNA). Upon binding viral RNA, Rig-I interacts with the mitochondrial antiviral signaling protein (MAVS) via its CARD domains, activating the IRF3/7 and NF-κB pathways to induce the production of type I interferons and pro-inflammatory cytokines. This protein plays a central role in defending against RNA viruses (e.g., influenza virus, hepatitis C virus), and its dysfunction is closely associated with autoimmune diseases and increased susceptibility to viral infections.
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