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350. GLP 1 Agonists: Mechanisms to Applications with Dr. Dennis Bruemmer Lilly is now pharma's top revenue company. It just got FDA approval for an oral GLP 1, but Wall Street isn't celebrating Drug Discovery and Development Retatrutide Beat Semaglutide by 7.9% in Phase 2 Here's the Trial Data GLP 1 receptor agonists show anti cancer benefits beyond weight loss New oral GLP 1 drugs could offer more options for weight loss Not an April fool's prank! The small molecule GLP 1 receptor agonist, orforglipron, has been approved by the FDA under the trade name, Foundayo. We discussed the data in a fall 2025 episode
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4.7 ★★★★★
Based on 9 reviews
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Product Reviews
★★★★★ 5
If you’re on the fence read this
Special Size: Low Stretch, Size: 40W x 30L, Color: Iced Light Wash, Special Size: Low Stretch, Size: 40W x 30L, Color: Iced Light Wash
In all honesty, I was skeptical about ordering jeans from Amazon. I’ve always bought my jeans in stores, but I figured I’d give it a shot. I ordered these jeans for an upcoming outdoor wedding because I wanted something lighter and thinner. They showed up today, and I threw them on. They fit great, feel good and comfortable, and they don’t look cheap. I’ll mainly be using these for outings, so I can’t really attest to the durability as far as working in them, but I’d still suggest them. For reference, I’m 5’8” and 230 lbs with a husky build—kind of fit, kind of fat.
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Reviewed in the United States on March 12, 2026
★★★★★ 5
These are great jeans
Special Size: Low Stretch, Size: 34W x 28L, Color: Grey Wash
These are great jeans for the price especially
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Reviewed in the United States on May 3, 2026
★★★★★ 4
Run big
Special Size: Rigid, Size: 40W x 30L, Color: Medium Blue Vintage
Bought for my husband and very loose in butt and legs and he's normally that size so maybe buy a size down
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Reviewed in the United States on April 22, 2026
★★★★★ 5
A Great Buy - But Might Be Too Long
Special Size: Low Stretch, Size: 34W x 32L, Color: Dark Midnight Wash
These jeans are an excellent buy! I have only bought Eddie Bauer jeans for the last 25 years, but this time I couldn't find my size in the correct style. I prefer classic/relaxed in dark blue. I don't like the "pre-washed" or worn look. The Dark Midnight Wash was exactly what I wanted - new jeans. The waist measurement was perfect. Unfortunately, the 32 length was waaay too long. (All the Eddie Bauers were 34x32). So I just did an exchange for a 34x30, which should be good. Eventhough the length was too long, I'm still giving 5 stars. Different manufacturers cut sizes differently. It is what it is. And the return process was EZ and the replacement size was in stock. Seriously, there is really no quality difference between these Amazon Essential jeans and my old $60 E.B.s No one sees the label anyway!
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Reviewed in the United States on January 26, 2026
★★★★★ 3
Weird sizing, snug in some places and much more “relaxed” in others
Special Size: Rigid, Size: 33W x 28L, Color: Black
Comfortable and close fit around waist, buttocks, crotch - but from thigh down trouser cuff it’s a VERY relaxed fit, much bigger than I need even with thick muscular legs. Not quite clown pants or bell bottoms, but a still a strange look. I’ll probably be sending them back.
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Reviewed in the United States on April 24, 2026