SKU: 99426201765

Zoetis INFORCE 3® Respiratory Vaccine

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Description

Zoetis INFORCE 3® Respiratory VaccineRespiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3 the market leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young

Respiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3® the market-leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young as 3 days old, at weaning, before moving to group pens, or with cows and heifers at prefreshening.

Indications
Helps protect against respiratory disease caused by BRSV, IBR and PI3.
Available As

Vials

For use with

Beef

Dairy

How it Works

As an intranasal respiratory vaccine, INFORCE 3® causes a local immune response with viral antibodies produced in the nasal passage where BRSV, IBR and PI3 are most likely to enter the animal’s system.

INFORCE 3® is the first commercially-available intranasal respiratory vaccine to help protect against respiratory disease caused by BRSV, while also protecting against IBR and PI3, to help get cattle off to a healthier, more productive start.

INFORCE 3 has a six-month duration of immunity claim for IBR protection, and a single-nostril administration claim. Additional research also demonstrated no maternal antibody interference for IBR and BRSV.2,3

Safe for all ages, types and classes of cattle

INFORCE 3® is safe for use in all types, ages and classes of cattle. INFORCE 3 was demonstrated safe for use in very young, high-stress calves; weaned and high-stress stocker calves; and pregnant heifers and cows.

The Science Behind Effective Control

  • Intranasal administration works with the animal's immune system for fast, effective response
  • Helps prime the immune system for a memory response to subsequent vaccinations as well as disease challenges
  • Contains proprietary, temperature-sensitive IBR and PI3 strains that replicate most effectively in the upper respiratory tract
  • Stimulates interferon release for protection
  • Helps deliver a healthy start for young dairy calves

Proven Respiratory Disease Protection

  • In two different studies, all calves vaccinated with INFORCE 3 survived severe BRSV challenges in which 100% and 90% of unvaccinated controls either died or had to be humanely euthanized.4,5
  • INFORCE 3 was shown to help prevent respiratory disease caused by IBR and PI3 and reduce level and duration of viral shedding caused by IBR and PI3.6-8
  • A study comparing INFORCE 3 and TSV-2® demonstrated that vaccinating cows and heifers with INFORCE 3  prior to freshening helped support overall positive production:
    • 205 pounds more milk per cow per lactation9
    • Increased income per cow9

Directions

Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, mix well and administer 2 mL intranasally using a cannula. Place the 2-mL dose in a single nostril or place 1-mL in each nostril. 

Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age to avoid possible maternal antibody interference with immunization. Annual revaccination with a single dose is recommended. 

For further advice on revaccination frequency, consult your veterinarian.

PRECAUTIONS:

  1. Store at 2°-8°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

  2. Use entire contents when first opened.

  3. Sterilized syringes should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

  4. Inactivate unused contents before disposal.

  5. Do not vaccinate within 21 days before slaughter.

  6. Contains gentamicin as preservative.

  7. Fetal health risks associated with the vaccination of pregnant animals with modified live vaccines cannot be unequivocally determined during clinical trials conducted for licensure. Appropriate strategies to address the risks associated with modified live vaccine use in pregnant animals should be discussed with a veterinarian.

  8. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

References

  1. Based on number of doses and overall sales of respiratory vaccines. Animalytics Segment Data, Biologicals Therapeutic Category, Ending MAT May 2021.
  2. Mahan SM, Sobecki B, Johnson J, et al. Efficacy of Intranasal Vaccination With a Multivalent Vaccine Containing Temperature-Sensitive Modified-Live Bovine Herpesvirus Type 1 for Protection of Seronegative and Seropositive Calves Against Respiratory Disease. J Am Vet Med Assoc. 2016;248(11):1280-1286.
  3. Ellis JA, Gow SP, Mahan S, Leyh R. Duration of Immunity to Experimental Infection With Bovine Respiratory Syncytial Virus Following Intranasal Vaccination of Young Passively Immune Calves. J Am Vet Med Assoc. 2013;243(11):1602-1608.
  4. Data on file, Study Report No. 3131R-60-08-557, Zoetis Inc.
  5. Data on file, Study Report No. 3131R-60-09-669, Zoetis Inc.
  6. Data on file, Study Report No. 3131R-60-08-548, Zoetis Inc.
  7. Data on file, Study Report No. 3131R-60-09-720, Zoetis Inc.
  8. Data on file, Study Report No. 3131R-60-08-568, Zoetis Inc.
  9. Data on file, Study Report No. 10PETINF01, Zoetis Inc.
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Exchange/Return Notes
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SKU: 99426201765

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4.3 ★★★★★
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Boise, US
★★★★★ 3
less than 24 hours :/
Color: Grey Bear - Large, Color: Grey Bear - Large
smaller than i expected but had a strong interior that i was pleasantly surprised with. my lil lady very much enjoyed it, however it lasted less than 24 hours before the poor toy was skinned alive :( she loves plushies and she’s obsessed w his skin after tearing him apart. it does have a solid rubber interior that is still good as a toy, however i was hoping its skin would stay on longer than a day :( overall decent toy, 3 stars for being destroyed so quickly. wouldn’t recommend for strong chewers
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Reviewed in the United States on August 7, 2025
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Jen
Dallas, US
★★★★★ 5
Lasts long
Color: Panda Bear - Large
Perfect for super chewer dogs.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 14, 2026
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Michelle B.
Charlottesville, US
★★★★★ 4
Dachshund said “did I hear indestructible‽ Hold my ball”
Color: Grey Bear - Large
My 15lb Dachshund took this toy as a personal challenge. He heard me tell his human brother that it’s indestructible on the inside and said “hold my ball” promptly proceeding to schmurder the textile aspect of this adorable toy. I’d say it took him a total of 23 1/2 minutes to get to the center of this tootsie pop. I’m not even mad tho bc he had no interest in actually ingesting the outer part, and is totally into the inner toy, which is, for him, literally indestructible. It’s solid rubber, has a wild and fun bounce to it on multiple surfaces. Zodiac rates the squeak 10/10. It’s great especially for when I’m on a call or talking to someone in real life and can’t immediately throw said toy or pay complete attention to him. In conclusion: Your dog will probably love it, ((suggest to just keep an eye on them during the schmurder process and make sure you grab all the pieces that come off so none are swallowed)) Depending on your tolerance for squeaker pitch and frequency of squeak, it's a 4/10 in annoyance mostly bc it’s not a long drawn out squeak ((I can not tolerate those toys, they get “lost on top on my fridge” until I get up the courage to throw them out without him seeing)), it’s quick and requires a bit of effort to produce the sound however it’s a very high pitch squeak so it’s all up to your preference. I personally try to buy toys I can tolerate my dog loving on bc when he gets a new toy, it’s his favorite thing for a long time, like, it sleeps on the bed with us for the first month. Hope your fur child loves this as much as mine did. Not sure I’ll do the whole two in one toy thing again only he got through it so fast.
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Reviewed in the United States on December 25, 2025
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PurpleBookDragon
Bozeman, US
★★★★★ 5
LOVE BARK TOYS!!!
Color: Rad Herring - Medium
I got this toy for my 1yr old Husky/Heeler/(possibly)GSD (approx 42lbs) mix when she came to our home mid/late October of 2025 and the toy lasted until December 3rd 2025 when we had to assist her with opening the fabric to get the toy on the inside. It was a great fun toy for her and the inside toys still is and she loves playing with it. The durability of both the outside and inside toys are great for super chewers! I was glad there was no stuffing because I had gotten her a plush toy once before and she destroyed that immediately. The fabric on this was durable enough to withstand her chewing yet soft enough that it didn’t hurt her teeth. The colors were vibrant and fun for both toys even though wear and tear kinda took some of the fabric color away. I would definitely buy this again once the inside toy is no longer safe for her, especially since the size was perfect for her too.
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Reviewed in the United States on January 12, 2026
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ali
Belleville, US
★★★★★ 5
Good ball for strong chewers
Color: Cheeze Brawl - Large, Color: Cheeze Brawl - Large
My dog loves this ball except the outside fur gets gross really quickly. However, it’s easy to cutoff and underneath is a strong squeaky ball. It’s like two gifts in one. He’s a very heavy chewer and the ball lasts quite a bit.
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Reviewed in the United States on December 31, 2025

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