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Description
Sirt3 Recombinant Rabbit mAb (S-2005-62)Product Specification Host Rabbit Antigen Sirt3 Synonyms NAD dependent protein deacetylase sirtuin 3; NAD dependent protein delactylase sirtuin 3; Regulatory protein SIR2 homolog 3; SIR2 like protein 3 (mSIR2L3); Sir2l3 Immunogen Synthetic Peptide Location Cytoplasm, Mitochondrion Accession Q8R104 Clone Number S 2005 62 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Positive Sample mouse liver, mouse heart Purification Protein
Product Specification
| Host | Rabbit |
| Antigen | Sirt3 |
| Synonyms | NAD-dependent protein deacetylase sirtuin-3; NAD-dependent protein delactylase sirtuin-3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3 (mSIR2L3); Sir2l3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Mitochondrion |
| Accession | Q8R104 |
| Clone Number | S-2005-62 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | mouse liver, mouse heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Ms |
Background
Sirt3 protein, a member of the sirtuin family, is primarily located in the mitochondria. It is an NAD-dependent deacetylase that plays a crucial role in regulating various cellular processes. Sirt3 can deacetylate numerous target proteins, thereby influencing metabolism, stress resistance and aging. For example, it helps to enhance the activity of certain metabolic enzymes, promoting the breakdown of fatty acids and the generation of energy. Additionally, Sirt3 is involved in the response to oxidative stress, protecting cells from damage caused by reactive oxygen species. Its expression and activity are often altered in various diseases, making it a potential therapeutic target for conditions like metabolic disorders and neurodegenerative diseases.
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